Femara 2 5 mg Tablets Summary of Product Characteristics SmPC emc

Published On January 9, 2025 Published By admin

Femara 2 5 mg Tablets Summary of Product Characteristics SmPC emc

However, if it is almost time for the next dose (within 2 or 3 hours), the missed dose should be skipped, and the patient should go back to her regular dosage schedule. Doses should not be doubled because with daily doses over the 2.5 mg recommended dose, over-proportionality in systemic exposure was observed (see section 5.2). It is important to follow the recommended dosage and duration of use as advised by a healthcare professional. Regular monitoring of hormone levels and overall health is essential during the usage period. Being such a powerful Aromatase Inhibitor, the compound is great when it comes to combat emergency situations related to too high estrogen levels. Such situations are happening, usually, when bodybuilders are using aromatizable (also called wet) steroids like for example Testosterone, Boldenone, Nandrolone, Methandrostenolone or other types of steroids.

One controlled double-blind trial was conducted comparing Femara (letrozole) 2.5 mg to tamoxifen 20 mg as first-line therapy in postmenopausal women with advanced breast cancer. In 907 women, letrozole was superior to tamoxifen in time to progression (primary endpoint) and in overall objective response, time to treatment failure and clinical benefit. Plasma levels of LH and FSH are not affected by letrozole in patients, nor is thyroid function as evaluated by TSH, T4, and T3 uptake test. • Neo-adjuvant treatment of postmenopausal women with hormone receptor positive, HER-2 negative breast cancer where chemotherapy is not suitable and immediate surgery not indicated. In postmenopausal patients with advanced breast cancer, daily doses of 0.1 mg to 5 mg suppressed plasma concentration of oestradiol, oestrone, and oestrone sulphate by 75-95% from baseline in all patients treated.

Oral administration of letrozole to female rats resulted in decreases in mating and pregnancy ratios and increases in pre-implantation loss. In repeated-dose toxicity studies in rats and dogs up to 12 months, the main findings observed can be attributed to the pharmacological action of the compound. Plasma protein binding of letrozole is approximately 60%, mainly to albumin (55%). The concentration of letrozole in erythrocytes is about 80% of that in plasma.

  • For beginners, a typical dosage of Letrozol 2,5 mg is 0.5 mg to 1 mg per day.
  • Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, or have a history of osteoporosis (thinning or wasting of bones).
  • In the letrozole arm, total cholesterol levels were relatively stable over time, giving a statistically significant difference in favour of tamoxifen at each time point.
  • Letrozole the active substance is coming only in form of tablets so it should be taken by mouth, and is considered the most powerful Aromatase Inhibitor (AI) available.

DOSAGE AND ADMINISTRATION

Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, or have a history of osteoporosis (thinning or wasting of bones). Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Your doctor may perform some blood tests to check for vitamin D level or bone density before and during treatment. The Sequential Treatments Analysis (STA) addresses the second primary question of BIG 1-98, namely whether sequencing of tamoxifen and letrozole would be superior to monotherapy. There were no significant differences in DFS, OS, SDFS, or DDFS from switch with respect to monotherapy (Table 6).

Stimufol 2.5mg Tablet

In a 104-week mouse carcinogenicity study, no treatment-related tumors were noted in male mice. In female mice, a generally dose-related increase in the incidence of benign ovarian granulosa theca cell tumors was observed at all doses of letrozole tested. These tumors were considered to be related to the pharmacological inhibition of estrogen synthesis and may be due to increased LH resulting from the decrease in circulating estrogen. Consequently, after the first interim analysis the study was unblinded and continued in an open-label fashion and patients in the placebo arm were allowed to switch to Femara for up to 5 years. Over 60% of eligible patients (disease-free at unblinding) opted to switch to Femara. The final analysis included 1,551 women who switched from placebo to Femara at a median of 31 months (range 12 to 106 months) after completion of tamoxifen adjuvant therapy.

Uses of Letzol Tablet

Do not assume that too little estrogen is a good idea because it never is. Both males and females require a normal estrogen level and by taking https://royaloven.co.tz/anabolic-mix-effects-2/ too much of this powerful AI, you inhibit too much estrogen. We take delivery times seriously and provide secure shipping options to ensure that all our products are delivered in perfect condition every time. Our secure packaging also ensures that your order remains safe during transit. We offer speedy delivery options that get your orders to you within two to three business days. So, no matter how urgently you need them, Mucle Care will have them delivered right to your doorstep.

In the adjuvant and extended adjuvant setting, treatment with Femara should continue for 5 years or until tumour relapse occurs, whichever is first. For beginners in sports, a recommended starting dosage of Letrozol 2,5 mg is 0.5 mg every other day. More experienced athletes may require a higher dosage, typically ranging from 1 to 2.5 mg per day. It is crucial to consult with a qualified specialist to determine the most suitable dosage for your specific needs.